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Biography
Dr. James M. Karlinsey is an Assistant Professor of Chemistry at Penn State Berks. Dr. Karlinsey's research is focused on developing new analytical techniques to control microscale chemical reactions using microfluidic devices. The field of microfluidics combines elements of surface chemistry, device engineering, and instrument development to enable the manipulation of nanoliter and picoliter volumes of sample. Dr. Karlinsey's previous research involved the electrophoretic separation and multicolor laser-induced fluorescence detection of biomolecules on glass microchips. Samples included phycobiliproteins, which add pigmentation to algae, and DNA fragments for human identification and clinical diagnostics (e.g., anthrax). Current research involves the development of microreactors in plastic devices for enzyme analysis.
Publications
Leslie, Daniel C.; Easley, Christopher. J.; Seker, Erkin; Karlinsey, James M.; Utz, Marcel; Begley, Matthew R.; Landers, James P. Frequency-Specific Flow Control in Microfluidic Circuits with Passive Elastomeric Features. Nature Physics (2009), 5, 231-235.
Karlinsey, James M.; Landers, James P. AOTF-Based Multicolor Fluorescence Detection for Short Tandem Repeat (STR) Analysis in an Electrophoretic Microdevice. Lab on a Chip 2008, 8(8), 1285-1291.
Easley, Christoper J.; Karlinsey, James M.; Bienvenue, Joan M.; Legendre, Lindsay A.; Roper, Michael G.; Feldman, Sanford H.; Hughes, Molly A.; Hewlett, Erik L.; Merkel, Tod J.; Ferrance, Jerome P.; Landers, James P. A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability. Proceedings of the National Academy of Sciences (2006), 103(51), 19272-19277.
Karlinsey, James M.; Monahan, Jennifer; Marchiarullo, Daniel J.; Ferrance, Jerome P.; Landers, James P. Pressure Injection on a Valved Microdevice for Electrophoretic Analysis of Submicroliter Samples. Analytical Chemistry (2005), 77(11), 3637-3643.
Education
Ph.D., Analytical Chemistry, University of Virgina
B.S., Biochemistry and Philosophy, University of Scranton